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FACTS AVAILABLE IN THE LEAFLET:
Presentation and Form
IV vial (sterile, white lyophilized powder) 600mg x 10's
Product Description
Each vial contains glutathione sodium 646mg equivalent to glutathione 600mg
Pharmacodynamic Properties
Glutathione is a physiologic tripeptide – a chain of three amino acids cystein, glycine and glutamic acid: and is irreversibly consume in the detoxification of electrophilic metabolites and xenobiotics. It is very efficient free radical scavenger and protects cell from noxious effect or reactive oxygen compound.
Enhanced oxidative stress has been implicated in the pathogenesis of several disorders; as made evident by the low glutathione levels found in immune compromised individuals , neuro-degenerative diseases such as multiple scelerosis, ALS, Alzheimer's and Parkinson's disease, artherosclerosos, male infertility, pregnancy complications, cataracts, cancer and HIV-infected patients
Published clinical and scientific research has demonstrated the protective effect of glutathione in several pathologic situation which cause cellular damage, as is the case of intoxications from substances such as ethyl alcohol, paracetamol, salicylates, Phenobarbital, tricyclic antidepressants, organophosphorous insecticides, etc.
The mechanism of neurotoxicity induced by chemotherapeutic agents has been proposed to involved the accumulation of platinum within he peripheral nervous system, especially in the dorsal root ganglia. A strategy optimal for reducing the neurotoxicity associated with platinum drugs may be the use of glutathione, which is able to prevent the initial accumulation of platinum adducts in the dorsal root ganglia.
Posology and mode of administration
Mild: 300-600mg slow IV or IM daily
Severe: 600-1200mg slow IV or IM daily
The dosage however is dependent on age, weight and clinical condition of the patient and should also be related to the dose and administrat |
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